Description

Glypican-3 (GPC3). Cell surface proteoglycan that bears heparan sulfate. Used as a marker for hepatocellular carcinoma (HCC). When attached to the cell surface, stimulates the growth of HCC cells by increasing canonical Wnt signaling.


Clinical trials

NCT03884751 - Hepatocellular Carcinoma
NCT02905188 - Hepatocellular Carcinoma
NCT04377932 - Hepatocellular Carcinoma
NCT02932956 - Hepatocellular Carcinoma
NCT04093648 - Hepatocellular Carcinoma
NCT02723942 - Hepatocellular Carcinoma
NCT04121273 - Hepatocellular Carcinoma
NCT03146234 - Hepatocellular Carcinoma
NCT03130712 - Hepatocellular Carcinoma
NCT02715362 - Hepatocellular Carcinoma
NCT03084380 - Hepatocellular Carcinoma
NCT02395250 - Hepatocellular Carcinoma
NCT02959151 - Hepatocellular Carcinoma
NCT02876978 - Lung Squamous Cell Carcinoma


Target gene expression

The following plot describes the expression, in different tissues and TCGA cancers, of the different isoforms of the gene GPC3.


Target essentiality


Protein properties

The following plot describes the target topology, highlighting the position of the endo-, ecto- and transmembrane domains, as well as the position of a signal peptide, when present.